Thursday, June 20, 2013 | Updated 4:57 IST
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Lab Update
NAT (nucleic acid amplification test) screening reduces window period as follows:
HIV> 11 days post infections
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NAT Testing for Blood Banks
The primary benefit of NAT is the ability to reduce residual risk of infectious window period (WP)
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Lab Tests for infertility for women
Luteinizing hormone (LH), follicle–stimulating hormone (FSH), prolactin, estradiol,
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Only tissue diagnosis is conclusive.
Only tissue diagnosis is conclusive. Where tissue diagnosis is not possible
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Other Lab Update Article
Anti–smooth muscle antibody (ASMA)
Anti–smooth muscle antibody (ASMA): To help diagnose chronic
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Mycoplasma pneumoniae IgG and IgM
Blood tests for antibody to M. pneumoniae are done:
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Prostate specific antigen (PSA)
Ejaculation can increase PSA levels by upto 0.8 ng/mL, though levels return to normal within 48 hours. There is no need to ask men to abstain from sexual activity prior to PSA measurement. However, if an
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Levels of total cholesterol
Levels of total cholesterol, LDL and apolipoprotein B
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Stool Examination
Diarrhea is a common symptom of a gastrointestinal disturbance.
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Antidiuretic Hormone
Also known as – Vasopressin; Arginine Vasopressin; AVP is done to help detect, diagnose, and
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Tests for Conn’s Syndrome
To diagnose primary hyperaldosteronism and to monitor the effectiveness of treatment
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Multiple myeloma (MM)
MM may first be detected during routine wellness testing, showing up as an abnormal total protein level, an elevated calcium level, a low white or red blood cell count, and/or moderate to large amounts of protein in the urine.
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Antidiuretic hormone
Also known as: Vasopressin; Arginine Vasopressin; AVP
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Polycythemia
Polycythemia is defined as an increase in total body erythrocyte mass. As opposed to the situation with anemias, the physician may directly measure RBC mass using radiolabeling by 51chromium, so as to
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Protein Electrophoresis
Immunofixation Electrophoresis To help diagnose and monitor multiple myeloma and a variety of
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TSH estimation by CLIA technology
Chemiluminescence Immunoassay (CLIA) detection using microplate luminometers provides a sensitive, high throughput, and economical alternative to conventional colorimetric methodologies, such as
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Mean Corpuscular Hemoglobin Concentration
MCHC (g/dL) = Hemoglobin (g/dL)/HCT (%) × 100 Reference values are 32–34 g/dL
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Renal Biopsy, Light Microscopy
Kidney biopsy has proven to be of value in the clinical evaluation and management of patients with undiagnosed kidney disease. The clinical setting may include acute renal failure, nephrotic syndrome, asymptomatic proteinuria
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Routine Stool Examination
Detection and identification of parasites: included are Giardia, Entamoeba histolytica (amoeba), helminth eggs
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Thrombocytopenia
Platelet count < 150,000/microL (Note: 2.5% of the normal population may have a platelet count lower than this).
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Blood ceruloplasmin
Decreased ceruloplasmin levels: May indicate Menke’s disease, Wilson’s disease (a rare copper storage disease), overdose of Vitamin C and aceruloplasminemia.
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Creatinine Clearance Test
Evaluates the rate and efficiency of kidney filtration. It is used to detect and diagnose kidney dysfunction and/or the presence of decreased blood flow to
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Celiac Disease tests
The best initial laboratory test for diagnosis of celiac disease is anti–tissue transglutaminase antibody (anti–tTG), IgA. If this test is positive, it is likely that the patient has celiac disease. If the
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Serum gastrin
To detect an overproduction of gastrin
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Liver function tests (LFTs)
To screen for, detect, evaluate and monitor for liver inflammation and damage.
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Anion gap
Increased serum anion gap reflects the presence of unmeasured anions, as in uremia (phosphate, sulfate), diabetic ketoacidosis (acetoacetate, beta–hydroxybutyrate), shock, exercise–induced physiologic anaerobic
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Serum phosphorus
Hypophosphatemia or low serum phosphorus levels can be seen in several biochemical derangements, including acute alcohol intoxication, sepsis,
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Acetaminophen
To determine if an overdose has occurred
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International Normalized Ratio
The International Normalized Ratio (INR) is used to monitor the effectiveness of blood thinning drugs such as warfarin (Coumadin). These anti–coagulant drugs help inhibit the formation of blood clots.
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AFB Smear and Culture
To help identify a mycobacterial infection; to diagnose tuberculosis (TB);
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Calcium
As part of a routine metabolic, electrolyte panel, in persons with kidney, bone, or nerve disease, or when symptoms of
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Serum Albumin
To screen for liver or kidney disease
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Phosphorus
Hypophosphatemia can be seen in a variety of biochemical derangements, including acute alcohol intoxication, sepsis, hypokalemia, malabsorption syndromes, hyperinsulinism, hyperparathyroidism, and
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Anticardiolipin antibodies
Anticardiolipin antibodies are used to help investigate inappropriate blood clot formation, to determine the cause of recurrent
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5–hydroxyindoleacetic acid
Also known as: HIAA; Serotonin metabolite
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Thyroid stimulating hormone (TSH)
TSH is produced by the pituitary gland. It stimulates the production and release of T4 and T3 by the thyroid gland. TSH testing helps to
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Serum calcium
Hypocalcemia (or low serum calcium level) must be interpreted in relation to serum albumin concentration (Some laboratories report a "corrected calcium"
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Platelet count
Thrombocytopenia (or low platelet count) is divided pathophysiologically into production defects and consumption defects based on examination of the bone marrow aspirate or biopsy for the presence of megakaryocytes.
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Stool Examination
Diarrhea is a common symptom of a gastrointestinal disturbance.
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Vitamin B1, Plasma
Thiamine, or thiamin, sometimes called aneurin, is a water–soluble vitamin of the B complex (vitamin B1), whose phosphate derivatives are involved in many cellular processes.
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